Read e-book online Analytical Method Development and Stability Studies of PDF

By Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu

ISBN-10: 3656948895

ISBN-13: 9783656948896

Master's Thesis from the yr 2011 within the topic drugs - Pharmacology, grade: 8.0, , path: B.Pharm.,M.Pharm, language: English, summary: A opposite section excessive functionality liquid chromatographic technique (HPLC) has been constructed for the tactic improvement validation of Carvedilol in bulk and pharmaceutical formula by utilizing YMC PACK professional 4.6 X a hundred and fifty mm (5µm Particle size). The cellular part was once Buffer: Acetonitrile: (70:30) and pH used to be adjusted to two pumped at a circulate cost of one ml/min and the eluents have been monitored at 320nm. Linearity used to be acquired within the focus variety of 10-90 μg/ml. The retention time of Carvedilol was once chanced on to be 3.2 minute. the tactic used to be proven for specificity, accuracy, precision, linearity, and restrict of detection, restrict of quantification, robustness and solubility balance. LOD and LOQ have been discovered to be 0.001 μg/ml and 0.011μg/ml respectively. the strategy used to be statistically demonstrated and RSD was once came upon to be under 2% indicating excessive measure of accuracy and precision of the proposed HPLC procedure. balance learn document published that the drug is vulnerable for acidic, alkaline, oxidative, photolytic and UV degradation. The drug is solid to thermal degradation. extra over the degradants have been good separated from its API. as a result of its simplicity, rapidness, excessive precision and accuracy, the proposed HPLC strategy can be utilized for identifying Carvedilol in bulk drug samples or in pharmaceutical dosage forms.

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Analytical Method Development and Stability Studies of Carvedilol by Kishanta Kumar Pradhan,Ranganadha Rao K,P. Srinivasulu


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