Get COX-2 Blockade in Cancer Prevention and Therapy (Cancer Drug PDF

By Randall E. Harris

ISBN-10: 1588290107

ISBN-13: 9781588290106

ISBN-10: 1617373044

ISBN-13: 9781617373046

The revelation that aspirin and aspirin-like compounds have notableantineo­ plastic houses has revolutionized melanoma study. COX-2 Blockade in melanoma Prevention and remedy chronicles the facts and provides fascinating new op­ portunities for using cyclooxygenase-2 (COX-2) blockade within the prevention and remedy of melanoma. The textual content is split greatly into 5 parts. First, an historic review records the clinical discovery ofCOX-2 and the pharma­ ceutical improvement of nonsteroidal anti inflammatory medications (NSAIDs) designed for selective COX-2 inhibition. the method during which crucial poly­ unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and melanoma improvement, and its interruption by way of COX-2 inhibition, is elucidated. this is often through a bit at the epidemiology of NSAIDs and cancers of the colon and breast, and different anatomic websites. those chapters mirror major melanoma safeguard as a result of the ordinary use of universal NSAIDs akin to aspirin and ibuprofen. a bit on animal versions of carcinogenesis provides accomplished proof that common NSAIDs inhibit numerous malignant neoplasms in vivo, and highlights contemporary findings which express that COX-2 blocking off brokers produce outstanding chemopreventive results opposed to colon melanoma and breast melanoma in addition to different malignancies. Genetic versions are provided confirming the severe function of COX-2 in carcinogenesis. part IV then discusses the molecular biology of COX -2 vis-a-vis the function of COX -2 and, to a lesser volume, COX -1, in modulating a couple of vital methods in molecular carcinogenesis corresponding to mutagen­ esis, phone department, angiogenesis, phone differentiation, and apoptosis.

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COX-2 Blockade in Cancer Prevention and Therapy (Cancer Drug Discovery and Development) by Randall E. Harris

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