Get Design of Regioselective Bilayer Floating Tablets of PDF

By Ajit Kulkarni,Manish Bhatia

ISBN-10: 3656855552

ISBN-13: 9783656855552

learn Paper (postgraduate) from the yr 2014 within the topic Pharmicology, grade: 2, , language: English, summary: the aim of the learn used to be to layout bilayer floating pills of Propranolol hydrochloride and Lovastatin to offer fast unlock of Lovastatin and regulated free up of Propranolol hydrochloride. Bilayer floating drugs created from layers, speedy unencumber layer and regulated liberate layer. Direct compression approach used to be hired for formula of the bilayer drugs. brief time period sped up balance reviews have been conducted at the ready pills. all of the formulations floated for greater than 12h. greater than ninety% Lovastatin used to be published inside 30 min. from the formulations. HPMC K4M and Xanthan gum retarded the discharge of Propranolol hydrochloride from the managed free up layer for 12h. After balance reports, obvious degradation of either the medicine have been chanced on however the drug content material was once discovered to be in the variety. Diffusion exponent (n) was firm for all of the formulations (0.53-7). in line with coefficient of correlation(R), the discharge of Propranolol hydrochloride was once chanced on to persist with combined unencumber development of Hixson-Crowell, Korsmeyer-Peppas and matrix, other than formula F6 and F9, which 0 order liberate trend. Statistical research published that there has been no major distinction in in vitro liberate development of the medicine prior to and after balance studies.

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Download e-book for kindle: Design of Regioselective Bilayer Floating Tablets of by Ajit Kulkarni,Manish Bhatia

Study Paper (postgraduate) from the 12 months 2014 within the topic Pharmicology, grade: 2, , language: English, summary: the aim of the research was once to layout bilayer floating drugs of Propranolol hydrochloride and Lovastatin to provide instant unencumber of Lovastatin and regulated liberate of Propranolol hydrochloride.

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Design of Regioselective Bilayer Floating Tablets of Propranolol Hydrochloride and Lovastatin for Biphasic Release Profile by Ajit Kulkarni,Manish Bhatia


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